Could Metformin be a Safe & Effective therapy for Neurodegenerative diseases

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Metformin, a commonly prescribed diabetes medication, is gaining attention for its potential anti-aging effects. The drug works by activating AMPK, an enzyme that helps regulate energy use in cells. This activation has far-reaching effects, including protecting against DNA damage, improving mitochondrial function, and reducing chronic inflammation, all of which are key factors in the aging process. Studies have shown that metformin can extend lifespan in animals and may do the same for humans.

Beyond its potential anti-aging benefits, metformin has shown promise in preventing and treating various age-related diseases. It has been found to reduce the risk of cancer, cardiovascular disease, obesity, and neurocognitive decline. The drug's ability to combat obesity is particularly noteworthy, as it helps the body burn fat and reduces insulin resistance. Metformin is also being investigated for its neuroprotective effects, with studies suggesting it may help prevent Alzheimer's and Parkinson's diseases.

While metformin is generally safe, there are some precautions to consider. It can interfere with vitamin B12 absorption, so supplementation may be necessary. In men, metformin may reduce testosterone levels, which can be addressed with topical testosterone creams. Overall, metformin is a promising drug with a wide range of potential benefits, including anti-aging effects and protection against age-related diseases.