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FAQ on Geroprotection

What is cellular senescence?

Cellular senescence is a state that cells enter when they stop multiplying but don't die off. This can occur due to disease, injury, or stress factors. Senescent cells can linger in the body and release substances that trigger inflammation.

How does cellular senescence affect the body as we age?

As we age, our immune systems become less efficient at clearing senescent cells. These cells accumulate and can contribute to age-related decline and conditions. They can impair the ability to withstand stress, recover from injuries, and maintain cognitive function.

What is the "senescent secretome"?

The "senescent secretome" refers to the molecules and compounds released by senescent cells. While these can cause inflammation and damage, they also play important roles in processes like embryonic development, childbirth, and wound healing.

What are some age-related conditions linked to cellular senescence?

Cellular senescence has been connected to a variety of age-related conditions including cancer, diabetes, osteoporosis, cardiovascular disease, stroke, Alzheimer's disease and related dementias, and osteoarthritis. It is also linked to declines in eyesight, mobility, thinking ability, and skin changes like sagging and wrinkling. Some researchers are investigating if senescent cells contribute to severe outcomes in older adults with COVID-19.

What is "senolytic" therapy?

Senolytic therapy involves using drugs or other interventions to selectively eliminate senescent cells from the body. The goal is to reduce the negative effects of accumulating senescent cells and potentially improve health span and treat age-related diseases.

What research has been done on senolytic therapies?

Researchers have explored various senolytic approaches. For example, a combination of dasatinib and quercetin has shown promise in clearing senescent cells in both laboratory and human studies. Studies in mice have indicated that clearing senescent cells can delay age-related ailments, improve physical function, and potentially increase lifespan.

Is senolytic therapy safe for humans?

Research into the safety of senolytic therapies is still in early stages. While some studies have shown promising results, researchers emphasize the need for extensive clinical trials to confirm safety and effectiveness. They also highlight the importance of understanding the potential long-term consequences of eliminating senescent cells, as they have beneficial roles as well.

What is the future of cellular senescence research and senolytic therapies?

Research into cellular senescence and senolytic therapies is a rapidly growing field. Scientists are actively investigating the mechanisms by which senescence contributes to aging and disease, identifying biomarkers for senescent cells, and developing new strategies to target them. Collaboration across institutions like the National Institutes of Health (NIH) is facilitating progress, with a focus on translating these findings into clinical applications to promote healthier aging.