Unlock your Healthspan: Longevity enhanced by NAD+ & Quercetin/Fisetin

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Briefing Document: NAD+ and Anti-Aging Strategies

Main Themes:

• The role of NAD+ decline in the aging process.
• Potential strategies to boost NAD+ levels and their synergistic effects with other compounds for increasing healthspan.
• The importance of addressing various hallmarks of aging, including inflammation, telomere attrition, and proteostasis, in anti-aging interventions.

Key Ideas and Facts:

Source 1: "Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.pdf"

• NAD+ Decline and Aging: "Disruption of proper NAD+ and loss of protective sirtuin activity have emerged as the prime targets for NAD+-based interventions [30]." Administration of NAD+ precursors, like NMN and NR, has shown promising results in alleviating age-related decline.
• Importance of NAD+ Precursors: "Adequate intracellular levels of NAD+ are crucial for the proper function of several biological processes," including mitochondrial metabolism and PARP inhibition. The study highlights the use of NMN as an effective method for boosting NAD+ levels. Clinical trials show positive results in areas like telomere attrition, gut microbiome, and even sleep quality.
• Synergistic Supplementation: The document emphasizes the potential of combining NAD+ boosting strategies with other compounds for maximizing health benefits. "The synergistic effects when considering NAD+ synergy, CD38 inhibition, and methylation support are all important factors." Stilbenes like resveratrol and pterostilbene, flavonoids, and carotenoids are discussed as potential synergistic agents.
• Resveratrol's Multifaceted Role: Resveratrol, a natural polyphenol, is presented as having a wide range of potential benefits, including antioxidant effects, SIRT1 pathway activation, and neuroprotection. It is suggested that combining resveratrol with NMN can yield enhanced positive outcomes.

Source 2: "Therapeutic antiaging strategies Copy.pdf"

• Hallmarks of Aging: This review provides a comprehensive overview of the nine hallmarks of aging, outlining their impact on the aging process. It emphasizes that targeting these hallmarks provides a framework for developing effective anti-aging therapies.
• Anti-inflammatory Approaches: "Chronic inflammation is one of the major contributors to age-associated diseases and aging," the study states, highlighting the importance of anti-inflammatory drugs in anti-aging strategies. This source discusses a range of anti-inflammatory agents, including NSAIDs, spermidine, and aspirin.
• Telomere Reactivation: Telomere shortening is recognized as a critical marker of aging. The document explores various strategies for telomere reactivation, including telomerase activators, TERT transcription activators, and even gene therapy.
• Epigenetic Drugs: Epigenetic modifications are increasingly recognized for their role in the aging process. "Chromatin is intensely altered during aging," the study observes, pointing to the potential of epigenetic drugs like HDAC inhibitors to reverse age-related changes.
• Mitochondrial Health: Mitochondrial dysfunction is another hallmark of aging. This source emphasizes the importance of maintaining mitochondrial health and discusses interventions like mitophagy modulators, including resveratrol, to address this issue.
• Multiple Pathways for Intervention: The review highlights the complex nature of aging, involving a multitude of interconnected pathways. It explores strategies targeting mTOR and IIS signaling, AMPK and Sirtuin activation, and even the use of stem cell therapies and non-coding RNAs as potential interventions for extending lifespan and healthspan.

Quotes:

• Source 1: "Targeting the hallmarks of aging exists as a model which would allow for interventions ameliorating these processes: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication."
• Source 2: "Emerging evidence has been focused on examining the genetic pathways and biological processes in organisms surrounding these nine hallmarks. From here, the therapeutic approaches can be addressed in hopes of slowing the progression of aging."

Conclusion:

These sources emphasize the complexity of the aging process and the need for multi-pronged approaches to extend healthspan. Boosting NAD+ levels is a promising strategy, particularly when combined with interventions targeting other hallmarks of aging. Further research and clinical trials are crucial to fully understand the potential of these anti-aging interventions in humans.

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